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更年期对多发性硬化症的影响残疾进展

Francesca Bridge^1,2, Paul G Sanfilippo¹, Chao Zhu¹

¹Department of Neuroscience, School of Translational Medicine, Monash University.

|September 29, 2025

概括

更年期不会显著增加患有多发性硬化症 (MS) 的女性的残疾进展. 这项研究没有发现更年期与MS症状恶化或发展为继发性进展性MS之间的联系.

科学领域:

神经学神经学
生殖健康生殖健康
流行病学流行病学

背景情况:

大多数患有多发性硬化症 (MS) 的女性在疾病过程中经历更年期.
更年期对多发性硬化症进展的影响仍然不太清楚.

研究的目的:

调查更年期是否会改变患有复发性多发性硬化症的女性残疾进展的风险.
分析更年期和关键MS疾病里程碑之间的关联.

主要方法:

使用MSBase注册表的前性数据进行回顾性队列研究.
包括987名患有复发性多发性硬化症的妇女,分析更年期状态和残疾进展 (扩展残疾状态量表 - EDSS).
使用考克斯比例危险模型,根据MS发病时的年龄,疾病持续时间,基线EDSS,复发和疾病修饰疗法进行调整.

主要成果:

更年期与6个月确认残疾进展 (CDP) 或二次进展性MS (SPMS) 的风险增加无关.
对CDP和SPMS的危险比分分别为0.95 (95%CI,0.70-1.29) 和1.00 (95%CI,0.60-1.67).
在二次分析中,更年期并不是EDSS恶化的重要转折点.

结论:

研究结果不支持更年期作为MS老年妇女残疾进展的主要驱动因素.
虽然生殖衰老可能有助于增长,但它不是增加残疾的主要因素.
进一步的研究可能会探索MS体质和生殖衰老的相互作用.

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