生命必需8级和肝纤维化之间的关联 - NHANES 2017-2018年
1Department of Infection. Tongxiang First People's Hospital.
Nutricion hospitalaria
|September 29, 2025
概括
保持良好的心血管健康 (CVH) 与较低的肝纤维化率有关. 在生命的基本8 (LE8) 尺度上获得更高的分数显示,与肝纤维化患病率有显著的反向关系.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 肝纤维化和心血管疾病 (CVD) 有着复杂的联系.
- 使用生命的基本8 (LE8) 尺度的心血管健康 (CVH) 评估提供了一个全面的指标.
- 了解CVH和肝纤维化之间的相互作用对于公共卫生战略至关重要.
研究的目的:
- 调查美国成年人肝纤维化和整体心血管健康 (CVH) 之间的关联.
- 分析个别LE8指标与肝纤维化之间的关系.
- 探索潜在的非线性关联和子组差异.
主要方法:
- 这是一项采用国家健康和营养检查调查 (NHANES) 数据 (2017-2018) 来自3,609名参与者的横截面研究.
- 根据LE8分数 (0-100) 将心血管健康分类为高,中和低.
- 使用振动控制弹性图 (VCTE) 查肝纤维化,以测量肝硬度 (LSM > 8.0 kPa);统计分析包括回归和光滑曲线拟合.
主要成果:
- 在整体CVH和肝纤维化之间观察到显著的反向关系.
- 较高的CVH得分,特别是在高类别中,与肝纤维化几率降低密切相关 (OR = 0.10,95% CI [0.05,0.19]).
- 饮食,体力活动,血压,葡萄糖和BMI与肝纤维化相反相关;睡眠,脂质和尼古丁暴露没有显著联系.
结论:
- 心血管健康 (用LE8测量) 和肝纤维化之间存在显著的负面关联.
- 保持最佳的CVH可能在减少肝纤维化和肝硬化患病率方面发挥作用.
- 这些发现强调了促进心血管健康以缓解肝病进展的重要性.
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