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在同步聚焦激光内显微镜下进行横支气管结晶检查指导外周肺病变:试点研究

Daniela Gompelmann¹, Anastasia Papaporfyriou¹, Christina Bal¹

¹Division of Pulmonology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.

Respiration; international review of thoracic diseases

|September 29, 2025

概括

这项研究表明,由基于同步探针的共聚焦激光内显微镜 (pCLE) 引导的横支气管冷活检是诊断周围肺病变的安全和可行的方法. 这种技术允许在活检过程中实时成像指导.

科学领域:

肺部病理学肺部病理学
干预性肺病学干预性肺病学
医疗成像医学成像

背景情况:

导向射线内支气管超声波 (rEBUS) 导向的横支气管活检 (TBB) 是外围肺病变的标准.
目前的rEBUS-TBB需要在活检前移除探头,限制了同时指导.
在TBB期间,需要基于内分支膜成像的指导.

研究的目的:

根据基于同步探针的共聚焦激光内显微镜 (pCLE) 指导,评估横支气管冷活检的安全性和可行性.
评估PCLE在指导冷探针放置在外围肺病变中的实用性.

主要方法:

一项前性试点研究,涉及15名患有可疑肺病变的患者.
在rEBUS和光学指导下同时插入冷探头和AQ FlexTM探头.
pCLE成像用于优化跨支气管活检 (TBB) 之前的冷探针位置.

主要成果:

在pCLE指导下同时进行的横支气管冷活检在11名患者中成功进行,没有并发症.
在病变中并行插入冷探头和AQ FlexTM探头始终是可以实现的.
在PCLE"工具在损伤"信号和恶性瘤确认之间观察到82%的一致性.

结论:

通过同时PCLE指导的横支气管冷活检对于周围肺病变是可行的和安全的.
这项研究表明了PCLE在TBB实时指导方面的潜力.
需要进一步的研究来确定PCLE成像的额外临床益处.

关键词:

同聚焦激光内分显微镜.低温生物检查 (Cryobiopsy) 是一个非常简单的方法.肺部结节肺部结节

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