肠道准备进行结肠镜检查:患者的观点
Gianeugenio Tontini1,2, Cristiano Spada3, Franco Radaelli4
1Department of Pathophysiology and Organ Transplantation, University of Milan, Milan, Italy.
Digestive diseases (Basel, Switzerland)
|September 29, 2025
概括
在接受结肠镜检查的患者中,曼尼托尔肠道制剂显著优于聚乙烯糖醇-asc (PEG-ASC). 曼尼托尔显示出优异的可接受性和耐受性,这表明它可能是准备结肠镜的理想选择.
科学领域:
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 结肠镜检查需要有效的肠道准备,尽管患者对分剂量计划抱怨,但通常使用聚乙烯糖醇-asc (PEG-ASC).
- 曼尼托尔是一种具有快速作用的可口,低体积的替代品,使其成为PEG-ASC的潜在替代品.
研究的目的:
- 为了比较患者报告的同一天口服曼尼托尔的可接受性和耐受性与分剂量2L PEG-ASC用于结肠镜准备.
- 评估曼尼托和PEG-ASC对患者满意度,症状和活动限制的影响,使用肠道清洁影响评估 (BOCLIR) 问卷.
主要方法:
- 一项国际,多中心,随机的III期研究 (SATISFACTION) 涉及476名完成BOCLIR问卷的患者.
- 患者被随机分配,接受同一天的口服曼尼托尔或分剂量治疗方案2L PEG-ASC.
- 在BOCLIR问卷中,对患者的体验进行了满意度,症状和活动限制等级的评估,较高的分数表明体验更差.
主要成果:
- 在总的BOCLIR得分中观察到一个统计学上显著的差异,有利于曼尼托尔 (最小平方平均差异: -8.01; 95% CI: -10.70至 -5.31; p < 0.0001).
- 与PEG-ASC相比,曼尼托尔在接受性和耐受性方面表现出优异的患者报告结果.
- 结果表明,使用曼尼托尔肠道制剂的患者体验明显改善.
结论:
- 与PEG-ASC相比,使用曼尼托尔进行肠道制备对患者来说是显著更容易接受和耐受的.
- 从患者的角度来看,曼尼托尔代表了对结肠镜准备的高度可取选择.
- 根据患者报告的结果,曼尼托尔可以被认为是近乎理想的肠道准备剂.
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