身体活动与接受化疗的患者的运动能力有关:一项试点随机对照试验
Alexis Antonucci1, Alexander R Lucas2,3, Juliana Costa4
1School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States of America.
PloS one
|September 29, 2025
概括
接受心脏毒性治疗的癌症患者在6个月的干预期间保持了体力活动和运动能力. 更高的体力活动可能有助于减少治疗后的运动不耐受.
科学领域:
- 在瘤学瘤学.
- 运动生理学 运动生理学
- 康复 康复 康复 康复
背景情况:
- 运动不耐受是癌症患者在积极治疗期间面临的常见挑战.
- 潜在的心脏毒性疗法可能会加剧运动限制.
- 一项试点研究调查了体育活动干预 (PAI) 与健康生活方式教育 (HLI) 对体育活动和运动能力的影响.
研究的目的:
- 为了评估与HLI相比6个月的PAI对加速计衍生体力活动 (PA) 措施的影响.
- 为了确定PA水平 (每天步骤,每周中等到强烈的PA [MVPA] 分钟) 和次最大运动能力 (6分钟步行距离 [6MWD]) 之间的关联.
- 在接受心脏毒性治疗的癌症患者中评估PA和6MWD的变化.
主要方法:
- 一项试点随机对照试验,共有33名参与者 (乳腺癌或淋巴瘤) 被分配给PAI或HLI (2:1比).
- 以患者为中心的运动训练是根据个人治疗和功能状态量身定制的.
- 对PA和6MWD的客观评估是在基线,3个月和6个月进行的.
主要成果:
- 在基线时,PAI组的参与者平均每天走8330步,每周MVPA133分钟,HLI组的参与者平均每天走7800步,每周MVPA109分钟.
- 在6个月的研究期间,两组都保持了他们的活动水平.
- 在3个月的步骤/天和6MWD之间发现了显著的关联 (r=0.51,p=0.04).
结论:
- 无论是PAI和HLI干预措施都帮助维持癌症患者的体力活动水平和亚最大运动能力长达6个月.
- 在PAI组中观察到在6MWD中具有临床意义的,但不具有统计意义的益处.
- 较高的体力活动水平显示出潜在的关联性与减少运动不耐受性后的Anthracycline治疗.
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