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在可逆胆固醇形成的小鼠模型中的动态胆固醇细胞反应:巨细胞重塑和NF-Y介导的TGFβ1表达

Kirsta E Olson1, Anuradha Krishnan1, Patrick Splinter1

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States.

American journal of physiology. Gastrointestinal and liver physiology
|September 29, 2025
PubMed
概括

胆固醇酶中的胆固醇细胞通过CX3CL1激活巨细胞,上调细胞因子风暴路径,并激活NF-Y,通过TGFβ1.1.促进纤维化. 这揭示了肝病的关键机制.

关键词:
在CXC中,CXC是CXC化学基因.库弗弗细胞是库弗弗细胞.在 Ly6C 中.胆固醇的发生.肝脏纤维化 肝脏纤维化

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