在慢性精神分裂症和首次住院精神分裂症中,通过N170调制指数化情感面部处理缺陷
Alfredo L Sklar1, Rachel Kaskie1, Dean F Salisbury1
1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
面部情绪识别随着精神分裂症的慢性化而下降. 首次住院的精神分裂症患者显示保留了N170情绪调节,与慢性患者不同,他们也显示了与负面症状的联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 面部情绪识别对社会互动至关重要,在精神分裂症中受损,导致社会缺陷.
- 与N170事件相关的潜在成分对健康个体的情绪面部表情敏感.
- 以前的研究表明,N170通过情绪调节可能会在慢性精神分裂症中受损.
研究的目的:
- 通过情绪面部表情来研究N170振幅调制,与对照组相比,在首次住院的精神分裂症 (FHSz) 和慢性精神分裂症 (ChSz) 患者中.
- 探索N170调制与精神分裂症症状严重程度之间的关系.
主要方法:
- 使用脑电图 (EEG) 来记录FHSz,ChSz,年轻对照 (YC) 和老对照 (OC) 中的P9/P10电极的N170振幅.
- 参与者执行了面部情绪检测任务,涉及中性和情绪面部 (快乐,愤怒,厌恶,恐惧,悲伤).
- 用积极和消极综合征尺度 (PANSS) 评估症状严重程度.
主要成果:
- 通过面部情绪观察到FHSz和YC的N170振幅调制,但与OC相比,在ChSz没有.
- FHSz参与者缺乏在YC中看到的N170反应的典型右半球侧面化.
- 在ChSz中,减少N170调制与PANSS负症状得分相反相关.
结论:
- 精神分裂症与处理情绪面部表情的渐进性损伤有关,如减少N170调制所示.
- 虽然首次住院的患者保留了一些情绪处理能力,但慢性患者表现出与负面症状相关的缺陷.
- 这些发现表明,影响N170发电机的渐进性神经病理有助于精神分裂症中持续存在的社会缺陷.
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