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Updated: Jan 16, 2026

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
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失调的光滑肌细胞增殖和基因表达是ACTA2变体相关的骨髓变异的基础

Mark E Pepin1,2,3, Richard N Mitchell3, Rajat M Gupta1,3

  • 1Division of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.

American journal of physiology. Heart and circulatory physiology
|September 29, 2025
PubMed
概括

一种新的α-2光滑肌肉动因 (ACTA2) 突变通过促进血管光滑肌肉细胞增殖,驱动胸前大动脉动脉瘤. 这项研究使用了存档组织上的单核RNA测序来揭示疾病机制,并证明FFPE兼容的snRNA-seq实用性.

关键词:
在ACTA2中使用ACTA2.遗传学 遗传学 遗传学 是一个非综合征性风脉动动脉损伤.一个单细胞RNA测序.胸前大动脉动脉瘤是什么?

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