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Updated: Jan 16, 2026

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CAR-SPLASH识别出涉及动态合和替代拼接的新生mRNA前结构

Hossein Shenasa1, Nova Fong1, Benjamin Erickson1

  • 1RNA Bioscience Initiative, Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045.

Proceedings of the National Academy of Sciences of the United States of America
|September 29, 2025
PubMed
概括

研究人员发现了RNA结构,称为"RNA动态开关",控制mRNA前拼接. 用反感性寡核酸破坏这些开关会改变替代拼接结果,揭示了转录和拼接之间的动态合机制.

关键词:
结构 RNA 结构 RNA 结构另一个替代拼接方法是拼接.动力合 动力合皮索拉伦交叉连接转录延长 延长 转录延长

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