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多功能外体驱动瘤免疫疗法敏感化:将内细菌转化为抗瘤战士

Xiaoqing Wei¹, Yongxin Zhang¹, Yuxin Chen¹

¹Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031, PR China.

|September 29, 2025

概括

这项研究使用已死的瘤细胞和装有铁纳米粒子和光热剂的外体来增强癌症免疫疗法. 这种方法将内细菌转化为抗瘤剂,增强对瘤和转移的免疫反应.

科学领域:

生物医学工程生物医学工程
癌症研究癌症研究
免疫治疗是一种免疫疗法.

背景情况:

内细菌可以通过隐藏在瘤细胞中来逃避免疫监测.
将与瘤相关的巨细胞 (TAM) 重编程为瘤杀伤性M1表型是癌症免疫疗法的关键策略.
开发有效地将治疗剂输送到内细菌并增强巨细胞活动的方法至关重要.

研究的目的:

开发一种基于外体的多功能系统,通过向内细菌来提高癌症免疫疗法的敏感性.
调查铁和光热疗法在诱导瘤细胞和细菌死亡方面的协同效应.
为了增强细菌的巨细胞化和随后的两极分化到M1表型.

主要方法:

用Fe3O4纳米粒子 (ferroptosis诱导剂) 和ICG (光热剂) 装载的多功能外体的构建.
使用死瘤细胞作为桥梁,将TAM与瘤内细菌连接起来.
采用CD47阻断来增强细菌的巨细胞化.
通过协同铁和光热疗法,免疫细胞两极分化和瘤抑制来评估治疗疗效.

主要成果:

多功能外体诱导了协同作用的铁和光热疗法,导致有效的瘤细胞和瘤内细菌死亡.
被杀死的瘤细胞表现出增强的免疫性,并与CD47阻断相结合,促进了巨细胞的细菌细胞分裂.
被吞的细菌成功地将TAM两极化为瘤杀伤性M1表型,增强抗瘤免疫力和T细胞透.
治疗导致显著抑制瘤生长和转移.

结论:

多功能外体有效地将内细菌转化为抗瘤战斗剂,使癌症免疫治疗敏感.
该策略克服了细菌逃避,并增强了巨细胞介导的抗瘤反应.
这种方法有望通过激发强大的抗瘤免疫力和抑制瘤进展来有效治疗癌症.

关键词:

这是一种抗瘤药物.异构体是什么? 异构体是什么? 外构体是什么?免疫治疗是一种免疫疗法.内细菌是一种口内细菌.与瘤相关的巨细胞.

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