无卵性个体的营养模式和不良妊娠结果:一个集群分析
Tetsuya Kawakita1, Yara H Diab1, Kazuma Onishi1
1Department of Obstetrics and Gynecology, Macon and Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, United States.
American journal of perinatology
|September 29, 2025
概括
富含反式脂肪,红肉和含糖饮料的饮食增加了不良妊娠结果的风险. 相反,富含维生素E,维生素A,蔬菜和水果的饮食与较低的风险有关.
科学领域:
- 营养流行病学 营养流行病学
- 孕产妇健康 孕产妇健康
- 在公共卫生领域的数据挖掘
背景情况:
- 饮食模式显著影响怀孕的结果.
- 确定与不良妊娠结果 (APO) 相关的特定饮食模式对于有针对性的干预至关重要.
- 之前的研究已经探讨了饮食与怀孕结果的联系,但明确的模式识别需要先进的分析方法.
研究的目的:
- 开发和应用一个k-means集群算法,以识别无卵性孕妇的不同食物摄入模式.
- 评估这些已识别的饮食模式与不良妊娠结果 (APO) 之间的关联.
- 探索特定营养素和食物组在怀孕健康方面的作用.
主要方法:
- 无卵性妊娠结果研究的二次分析:监测即将成为母亲 (nuMoM2b) 队列.
- K-means集群算法应用于335个从怀孕前3个月收集的验证问卷中的饮食变量.
- 修改Poisson回归用于计算饮食集群中APO的调整相对风险 (aRR),使用随机森林模型来确定特征的重要性.
主要成果:
- 在7,599名参与者中,确定了三个不同的饮食群.
- 集群2,以高摄入维生素E,维生素A,蔬菜和水果为特征,代表了健康的饮食模式.
- 与集群2相比,标志着高摄入的反式脂肪,多不和脂肪酸,红肉和含糖饮料的集群3显示出与增加的APO (aRR,1.19;95% CI:1.01-1.39) 的显著关联.
结论:
- 含高反式脂肪,多不和脂肪酸,红肉和含糖饮料的饮食模式与增加妊娠不良结果的风险显著相关.
- 相反,富含维生素E,维生素A,蔬菜和水果的饮食似乎可以防止不良妊娠结果.
- 这项研究强调了特定饮食模式在孕产妇健康和妊娠结果中的关键作用,强调了营养指导的必要性.
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