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Updated: Jan 16, 2026

Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
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通过NITAC介导的eIF4E2的ISGylation减弱了GSK3β的林导向激酶活性,从而赋予了细胞保护

Lan Li1, Jinjin Gong1, Huiting Liang1

  • 1College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.

The Journal of biological chemistry
|September 29, 2025
PubMed
概括

研究人员开发了一种基于纳米体的新型ISGylation Targeting Chimera (NITAC) 来激活eIF4E2的ISGylation. 这种工具通过抑制GSK3β激酶活性来保护细胞免受缺血性压力.

关键词:
在ISGylation中进行化.尼塔克 (NITAC) 是一个国际组织.在OGD/R中,细胞保护 细胞保护eIF4E2-GSK3ββ 的情况.林导向激酶是一种以林为导向的激酶.

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