便微生物群移植用于尿路感染
Paulína Belvončíková1, Roman Gardlík1
1Faculty of Medicine, Comenius University, Institute of Molecular Biomedicine, Slovak Republic.
概括
便微生物种移植 (FMT) 显示出治疗复发性尿路感染 (rUTIs) 的前景,特别是那些涉及多药耐药生物体的治疗. FMT可以减少感染频率并改善肠道微生物群的多样性,但需要进一步的研究来证实有效性和安全性.
科学领域:
- 微生物组研究的研究.
- 传染病 传染病 传染病
- 胃肠病学 胃肠病学
背景情况:
- 经常性泌尿道感染 (rUTIs) 构成了重大的临床挑战,多药耐药生物体 (MDROs) 和过度使用抗生素加剧了这一问题.
- 肠道微生物群失调越来越被认为是导致尿路感染易感性的因素,胃肠道作为尿病原体的储存库.
研究的目的:
- 本综述综合了关于便微生物群移植 (FMT) 作为RUTI治疗策略的当前证据.
- 它评估了微生物学和临床结果,机械洞察力和FMT在管理RUTI中的安全考虑.
主要方法:
- 使用PubMed和Web of Science进行了全面的文献审查,包括到2025年5月发表的研究.
- 包含的来源包括临床试验,队列研究,病例报告,经济分析和专家评论,重点关注 FMT 和尿道感染.
主要成果:
- FMT显示了减少RUTI发作的潜力,特别是在肠道失调或MDRO殖民的患者中.
- 研究报告说,FMT后尿路感染频率降低,MDRO负担降低,肠道微生物群多样性增强,一些患者实现了长时间的无感染期.
- 微生物组分析表明,尿病原体的丰富性减少,并转向类似捐赠者的微生物群落,尽管从捐赠者传播病原体是令人担忧的.
结论:
- 便微生物种移植是一种有前途的基于微生物的干预措施,用于管理复杂或抗生素耐药的RUTIs.
- 进一步的随机对照试验对于确定疗效,优化方案和解决安全问题至关重要.
- 标准化FMT实践对于其融入常规UTI管理至关重要.
相关概念视频
01:26Urinary Tract Infection I: Introduction
540
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
540
01:25Urinary Tract Infection II: Pathophysiology
570
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
570
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
253
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
253
01:17Urinary Tract Infection IV: Nursing Management
437
In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs...
437
01:50What is Monogastric Digestion?
75.0K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
75.0K