压力高血糖比率与入院中风严重程度之间的关联:在中国单中心队列中进行的一项回顾性研究
Yanmei Yu1,2, Zichen Rao3,4, Tingting Duan4,5
1Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
BMJ open
|September 29, 2025
概括
压力高血糖比率 (SHR) 与急性缺血性中风 (AIS) 患者中风严重程度有关. 较高的SHR表明中风的严重程度更高,观察到的值效应低于1.3.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 压力高血糖是急性缺血性中风 (AIS) 中常见的.
- 压力高血糖比率 (SHR) 可能反映在AIS期间的代谢压力.
- 了解SHR与中风严重程度的关联对于患者管理至关重要.
研究的目的:
- 评估AIS患者中SHR和基线中风严重程度之间的关联.
- 要确定这种关系是否非线性.
主要方法:
- 对1479名AIS患者进行了回顾性队列研究.
- 从空腹血葡萄糖和HbA1c计算的SHR.
- 使用NIH中风量表 (NIHSS) 评估中风的严重程度.
- 使用后勤回归,通用添加模型和值效应分析进行分析.
主要成果:
- 较高的SHR与较大的中风严重程度显著相关 (p<0.001).
- 在调整后,升高的SHR独立预测中度至重度中风 (OR=2.90).
- 非线性分析发现了SHR=1.3的值,在这个值以下的风险增加.
结论:
- 在AIS中,SHR是中风严重程度的独立预测指标.
- 低于1.3的SHR值可能表明代谢压力增加.
- SHR可以帮助早期对AIS风险分层,但应与其他临床指标一起使用.
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