在接种COVID-19疫苗后患有心肌炎的患者的心脏功能和症状的长期影响:ECHOVID-19长期研究
Mohammad Nizar Ramadan1,2,3, Filip Soeskov Davidovski4,2,3, Caroline Espersen4,2,3
1Cardiovascular Non-Invasive Imaging Research Laboratory, Copenhagen University Hospital - Herlev & Gentofte Hospital, Hellerup, Denmark mohammad.nizar.ramadan.01@regionh.dk.
Open heart
|September 29, 2025
概括
长期跟踪COVID-19疫苗相关心肌炎 (V-心肌炎) 显示轻度心脏功能障碍和一些患者的持续症状,尽管正常化生物标志物. 进一步监测是必不可少的.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- COVID-19疫苗相关心肌炎对心脏健康的长期影响尚不清楚.
- 评估心脏功能,炎症标志物和疫苗接种后心肌炎的症状至关重要.
研究的目的:
- 评估COVID-19疫苗接种后心肌炎患者的长期心脏功能,炎症生物标志物和症状.
- 为了比较疫苗相关心肌炎 (V-心肌炎) 与非疫苗相关心肌炎 (NV-心肌炎) 的结果.
主要方法:
- 在入院后大约2年内对17名V-心肌炎患者的随访.
- 评估包括心声回声,生物标志物,心电图,肺超声波 (LUS) 和症状问卷.
- 与NV心肌炎患者队列的比较.
主要成果:
- 在随访时,V-心肌炎患者表现出轻度的左心室 (LV) 功能障碍 (GLS 16.0%) 和腹功能障碍 (71%).
- 生物标志物正常化,但35%的人有持续的轻度炎症.
- 疲劳 (35%) 和胸痛 (41%) 是常见的症状;V型心肌炎患者的GLS比NV型心肌炎对照患者低.
结论:
- 长期随访显示轻微的LV和腹功能障碍,保存的RV功能,以及COVID-19疫苗后心肌炎的正常化生物标志物.
- 很大一部分患者经历了持续的症状,这强调了持续监测的必要性.
- 结果表明,与非疫苗原因相比,V-心肌炎可能导致微妙的长期心脏变化.
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