精确的扩散权重成像头部和部状细胞癌
Gloria J Guzmán Pérez-Carrillo1, Wenshang Wang1, Jingxia Liu1
1From the Department of Radiology (G.J.G.P.C., W.W., R.R., M.R., M.P., T.A., H.A.), Division of Public Health, Department of Surgery and Siteman Cancer Center (E.L, S.W.), GlaxoSmithKline and QMIC (M.B.), Department of Radiology, University of Michigan (D.M), Departments of Medical Physics and Radiology, Memorial Sloan Kettering Cancer Center (A.S-D.).
AJNR. American journal of neuroradiology
|September 29, 2025
概括
优化扩散权重成像 (DWI) 改善了脑皮细胞癌 (HNSCC) 的明显扩散系数 (ADC) 量化. 这种DWI协议显示了良好的测试重复测试可靠性,有助于临床评估HNSCC.
科学领域:
- 放射学和医学成像学 医学成像学
- 在瘤学瘤学.
- 生物标志物 生物标志物
背景情况:
- 头部和部状细胞癌 (HNSCC) 是一个重大的全球健康挑战,每年发病率和死亡率很高.
- 使用扩散权重成像 (DWI) 精确量化明显扩散系数 (ADC) 对于HNSCC评估至关重要,但需要优化可重复性协议.
- 现有的定量成像生物标志物 (QIB) 资料显示不同癌症类型的变化.
研究的目的:
- 为了优化扩散加权成像 (DWI) 序列用于头部和部区域成像.
- 建立可复制的表面扩散系数 (ADC) 度量,用于头部和部状细胞癌 (HNSCC).
- 为了使临床医生能够从HNSCC成像中的测量错误中区分真实的生理变化.
主要方法:
- 使用定量成像生物标志物联盟 (QIBA) 推的参数,高b值 (2000),Zoom-IT技术和幻影校准,开发了一个优化的头部和部DWI协议.
- 26名HNSCC患者接受了测试复试DWI扫描. 从46个细分的瘤区域中提取了明显扩散系数 (ADC) 值.
- 使用主体内变化系数 (wCV),重复性系数 (RC) 和类内相关系数 (ICC) 评估可重复性,使用手动和半自动细分.
主要成果:
- 优化的DWI协议表现出良好的测试-重新测试可靠性,具有0.8-0.83.3之间的类内相关系数 (ICC).
- 个体内变化系数 (wCV) 为5.2-5.4%,可重复系数 (RC) 为14.4%.
- 两个专家阅读器 (DICE分数为0.991和0.976) 进行的细分之间观察到很好的一致性.
结论:
- 优化的DWI协议为HNSCC提供了准确和可重现的ADC量化,与乳腺癌,肝癌和前列腺癌等其他癌症的指标相比或超过.
- 这些发现支持DWI的临床实用性,用于评估HNSCC瘤负担和治疗反应.
- 需要进一步的研究来完善参数,并将DWI作为HNSCC评估的标准,特别是用于瘤复发检测.
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