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Updated: Jan 16, 2026

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
09:16

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

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细胞外囊泡的蛋白质分解活动减弱了A-synuclein聚合的作用

Kostas Vekrellis1, Agaristi Lamprokostopoulou2, Katerina Melachroinou2

  • 1Center for Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece. vekrellis@bioacademy.gr.

NPJ Parkinson's disease
|September 29, 2025
PubMed
概括

小鼠大脑衍生的细胞外囊泡 (EVs) 含有蛋白酶,降解α-synuclein (α-syn) 并减少其病理传播. 这表明EV为同核蛋白病变提供了治疗点.

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Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo09:44

Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo

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