母亲的侵略是由休眠的激素敏感电路的短暂动员所驱动的
Stefanos Stagkourakis1, Paul Williams2, Giada Spigolon3
1SciLifeLab, Department of Neuroscience, Karolinska Institutet, Solna, Sweden. stefanos.stagkourakis@scilifelab.se.
Nature communications
|September 29, 2025
概括
雌性小鼠在哺乳期间表现出母性侵略性,原因是激素变化激活了休眠的神经回路. 这项研究确定了特定的神经元 (PMvDAT) 作为这一短暂的行为转变的关键性单态基质.
科学领域:
- 神经科学是一个神经科学.
- 行为生物学 行为生物学
- 内分泌学 在内分泌学.
背景情况:
- 攻击性通常是两性异形的,男性表现出比女性更高的水平.
- 母亲侵略是一种在哺乳期雌性中观察到的短暂行为,为研究成人行为可塑性提供了一个独特的模型.
- 导致母亲侵略的神经回路和激素机制尚未完全理解.
研究的目的:
- 为了调查性别偏见的行为程序是否依赖于性单态或双态的神经回路.
- 阐明孕产妇激素,前素和催产素在调节孕产妇侵略性的作用.
- 为了确定特定的神经基质和细胞机制,涉及到母亲的侵略.
主要方法:
- 在小鼠中利用了分子定义的腹前乳母神经元 (PMvDAT).
- 进行电生理学记录以评估神经元活动和荷尔蒙影响.
- 进行了功能增益和丧失实验,以操纵PMvDAT神经元活动.
- 观察到对母亲的侵略性和竞争性的社会行为的影响.
主要成果:
- PMvDAT神经元,在非哺乳期的雌性中通常处于静止状态,在哺乳期变得过度兴奋.
- 益生素和催产素通过突触前和突触后机制直接激发PMvDAT神经元.
- 调节PMvDAT神经元活动双向地影响了母亲的侵略.
- 激活PMvDAT神经元可以抑制其他社会行为.
结论:
- 鉴定了一种性单态的神经基质 (PMvDAT神经元) 参与母亲的侵略.
- 证明这些神经元集成荷尔蒙线索 (益生素,催产素) 来启用休眠的行为程序.
- 在雌性小鼠中提供了母性侵略的短暂表达的潜在机制.
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