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Updated: Jan 16, 2026

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直接circMAN1A2 ((2,3,4,5) -CENPB mRNA相互作用调节细胞增殖和癌症进展

Mei Cao1, Guo-Hua Yuan2, Shi-Meng Cao3

  • 1Center for Molecular Medicine, Children's Hospital of Fudan University and Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Nature communications
|September 29, 2025
PubMed
概括

替代循环化 (AC) 从单个基因产生多个circRNA. 一个特定的AC circRNA,circMAN1A2 ((2,3,4,5),通过稳定CENPB mRNA,促进结直肠癌 (CRC) 的进展,提供了一个潜在的治疗点.

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