心血管风险评估工具在MASLD (NAFLD) 患者的外部有效性:一个队列研究
Nima Motamed1, Mahmoodreza Khoonsari2, Mohammad Hadi Karbalaie Niya2,3
1Department of Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Scientific reports
|September 29, 2025
概括
心血管疾病 (CVD) 风险评估工具,特别是ACC/AHA工具,有效地预测了代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的心血管疾病事件. 这些工具有助于对MASLD患者的临床风险评估.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越多地被认为是与心血管疾病 (CVD) 风险增加相关的疾病.
- 在MASLD患者中准确预测心血管疾病事件对于及时干预和管理至关重要.
- 现有的心血管疾病风险评估工具需要在各种人群中验证它们的外部有效性,包括那些患有MASLD的人群.
研究的目的:
- 评估四种主要心血管疾病风险评估工具在预测MASLD患者心血管疾病事件中的外部有效性.
- 在这个特定的队列中比较ACC/AHA,SCORE,Framingham和SCORE2方程的预测性能.
主要方法:
- 前性队列研究 (Amol) 与1431名年龄在40-75岁的参与者进行了7年的跟踪.
- 使用ACC/AHA,SCORE,Framingham和SCORE2方程估计10年心血管疾病风险.
- 使用接收器运行特征 (ROC) 曲线评估区分能力.
主要成果:
- 该ACC/AHA工具在男性 (AUC:0.92) 和女性 (AUC:0.87) 两种情况下都显示出致命心血管疾病事件的最高预测能力.
- 此外,ACC/AHA工具在复合心血管疾病事件方面也表现出强的表现 (男性AUC:0.68,女性AUC:0.79).
- 评分方程显示出极好的预测能力致命的心脏事件与更少的变量.
结论:
- 心血管风险评估工具,特别是ACC/AHA工具,对于预测MASLD患者心血管疾病事件非常有价值.
- 建议ACC/AHA工具用于临床应用,用于评估MASLD妇女未来心血管疾病风险.
- SCORE方程为预测致命心脏事件提供了可行的替代方案,以其简单性而闻名.
相关概念视频
01:23Assessment of the Cardiovascular System I: Subjective Data
755
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
755
01:30Coronary Artery Disease I: Introduction
882
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
882
01:26Atherosclerosis III: Management
321
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
321