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使用低度气态低酸快速无活化气溶流感病毒
Koki Narihata1,2, Masaru Minamiguchi1, Miki Hata1
1R&D Center, Indoor Air Quality Business Division, Panasonic Ecology Systems Co., Ltd., Kasugai, Aichi, 486-8522, Japan.
Scientific reports
|September 30, 2025
概括
气态低酸 (HOCl(g)) 在潮湿的条件下有效地使气溶液中的H1N1流感A病毒失活. 这种安全的气体显示出控制空气传播感染在被占用空间的前景.
科学领域:
- 环境微生物学环境微生物学
- 传染病控制中的传染病控制
- 气溶科学是一门气溶科学.
背景情况:
- 有效的感染控制对于限制病原体传播至关重要,特别是通过气溶传播.
- 酸溶液喷雾已被用于空气传播病毒的失活,但其在气溶传播中的有效性仍然不确定.
- 气态低酸 (HOCl ((g)) 提供了一种潜在的安全方法,用于控制被占用环境中的感染.
研究的目的:
- 评估气态低酸 (HOCl(g)) 在控制气溶液 H1N1 流感 A 病毒感染方面的疗效.
- 为了确定相对湿度和气溶中的水含量对HOCl (g) 杀毒活性的影响.
- 为了比较HOCl ((g) 与臭氧 (O3) 在气溶环境中的抗病毒功效.
主要方法:
- 气溶液中的H1N1流感A病毒暴露于不同度的HOCl (g) (10-20ppb).
- 在不同相对湿度水平 (30%和50%) 下,对富含水和干气溶中的病毒感染性降低的评估.
- 对HOCl ((g) 与臭氧 (O3) 的比较分析和在粘真菌存在时的评估.
主要成果:
- 在数秒内,HOCl (g) 在富含水的气溶中显著降低了H1N1流感A病毒的感染力,降低了2.09-2.79日志.
- 在水蒸发后的干气溶中没有观察到显著的无活化.
- 在50%的相对湿度下,效果增加了3.06倍,而相对湿度为30%,表明湿度依赖.
- 即使在粘素存在的情况下,HOCl (g) 也表现出显著的杀毒活性 (2.34 log 减少),这表明气溶中的水含量有助于其作用.
- 对比分析表明,气溶中的水含量增强了HOCl介导的杀菌活性.
结论:
- 气态低酸 (HOCl(g)) 对气溶液中的H1N1流感A病毒有效,特别是在潮湿的条件下.
- HOCl ((g) 的杀菌效果取决于气溶中的水含量和相对湿度.
- HOCl (g) 是一个有希望的,安全的选择,用于控制空气传播的病毒感染在被占领的环境.
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