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Updated: Jan 16, 2026

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
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乳腺癌中的化疗诱导的CA重复DNA片段会触发抗瘤免疫反应

Xiaoqian Zhang1,2, Penghan Huang1,2, Huiping Chen1,2

  • 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Nature immunology
|September 30, 2025
PubMed
概括

癌症化疗产生DNA碎片,触发不同的免疫反应. 富含氨酸 (CA) 的DNA片段促进抗瘤免疫力,而缺乏CA的DNA片段导致免疫抑制,提供治疗潜力.

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