老年人的认知虚弱和部骨折手术后的短期预后
Bin Li1, Jing Chang2, Yiwei Wang3
1Department of Orthopedics, Beijing Haidian hospital, Beijing, 100080, China. jmily@126.com.
BMC geriatrics
|September 30, 2025
概括
在老年关节骨折患者中,认知虚弱很常见,导致更长的住院时间和更多的并发症. 早期检测是改善手术结果的关键.
科学领域:
- 老年医学 老年医学
- 整形外科手术 整形外科手术
- 认知科学 认知科学
背景情况:
- 部骨折在老年人群中是一个重要的健康问题.
- 认知障碍越来越被认为是影响老年人健康状况的一个因素.
- 了解这种人群中认知虚弱的患病率和影响对于改善患者护理至关重要.
研究的目的:
- 为了确定接受关节骨折手术的老年患者认知虚弱的患病率.
- 调查认知虚弱和短期术后并发症之间的关联.
- 确定认知脆弱性作为骨骨折修复后不良结果的潜在风险因素.
主要方法:
- 在接受关节骨折手术的老年患者 (≥65岁) 上进行了一项观察性研究.
- 用FRAIL尺度和蒙特利尔认知评估 (MoCA) 来评估患者的认知脆弱性.
- 在认知虚弱和非认知虚弱组之间比较了临床结果,包括住院时间和术后并发症. 多变量逻辑回归确定了独立的风险因素.
主要成果:
- 在159名注册患者中,有28.3%的人患有认知障碍.
- 认知虚弱小组的住院时间明显长 (15.6 vs 13.9 天),术后并发症的发生率更高 (24.4% vs 8.8%).
- 认知虚弱 (OR=2.73) 和查尔森并发症指数 (OR=1.31) 被确定为术后并发症的独立预测因素.
结论:
- 在患有部骨折的老年患者中,认知虚弱非常普遍.
- 在这个患者群体中,认知虚弱是短期术后并发症的独立预测因素.
- 早期识别和管理认知脆弱性可以改善老年骨折患者的风险分层和术后护理.
更多相关视频
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
17.0K
08:17A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
Published on: February 27, 2018
17.0K
相关概念视频
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
188
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
188
01:15Drug Dosing: Geriatric Patients
227
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
227
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
237
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
237
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
197
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
197
01:30Cognitive Development During Adulthood
780
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
780
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
232
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
232