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相关概念视频

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

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The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
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在lecanemab输注后D-二聚合物水平升高:一个病例报告

Ming Zou1, Shan-Shan Xu1, Shi-Guo Zhu1

  • 1Department of Neurology and Institute of Geriatric Neurology, the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

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|September 30, 2025
PubMed
概括

对阿尔茨海默病的莱卡内马布治疗可能会导致D-二次体水平升高,这表明血液凝块的潜在风险. 监测D-二聚物对于管理这些药物不良反应至关重要.

关键词:
药物不良反应 药物不良反应阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.粉样蛋白 β 是一种粉样蛋白.D-二聚子 D-二聚子莱卡内马布 (Lecanemab) 是一个

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科学领域:

  • 神经学 神经学
  • 药理学 药理学是指药理学的学科.
  • 免疫治疗是一种免疫疗法.

背景情况:

  • 莱卡尼马布是阿尔茨海默病 (AD) 的免疫疗法,可减缓认知能力下降.
  • 虽然有效,但其不良药物反应需要注意.

研究的目的:

  • 报告阿尔茨海默氏症患者用lecanemab治疗的复发性D-二元升高病例.
  • 为了调查lecanemab和D-dimer水平之间的潜在关联.

主要方法:

  • 一个82岁的中国阿尔茨海默病患者的病例报告.
  • 监测D-二元水平和与凝血参数 (aPTT,CRP,中性粒细胞百分比,血小板数) 的相关性.

主要成果:

  • 患者在lecanemab输注后经历了反复的D-二次元升高.
  • D-二聚合物水平与aPTT,CRP和中性粒细胞百分比呈正相关,与血小板数呈负相关.

结论:

  • 升高的D-二聚合物可能与lecanemab诱导的对血管粉样蛋白-β的 fagocytic反应有关.
  • 这表明在lecanemab治疗期间监测D-二烯对潜在的血栓栓塞事件.