与abemaciclib相关的急性间歇性炎成功用葡萄糖皮质类药物治疗:一个病例报告和文献综述
Mari Kumano1, Yujiro Maeoka2, Yuki Teragawa1
1Department of Nephrology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
BMC nephrology
|September 30, 2025
概括
这项病例研究报告了一名使用abemaciclib,一种循环素依赖性激酶 (CDK) 4/6抑制剂的患者的急性间歇性炎 (AIN). 通过脏活检及葡萄糖皮质激素治疗早期诊断改善了功能,突出显示了AIN风险,即使短期使用CDK4/6抑制剂.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 药物诱导的急性间歇性炎 (DI-AIN) 是一种常见的AIN类型,通常与T细胞介导的免疫反应有关,导致损伤.
- 已知用于乳腺癌的环素依赖激酶 (CDK) 4/6抑制剂会导致急性损伤 (AKI),包括AIN和急性管状缩 (ATN).
- 之前没有记录过与CDK4/6抑制剂abemaciclib相关的AIN病例.
研究的目的:
- 报告与abemaciclib使用相关的活检证明的急性间歇性炎 (AIN) 的第一个病例.
- 要突出AIN发展的潜力,即使短期接触CDK4/6抑制剂.
- 强调活检在管理abemaciclib诱导的损伤中的诊断意义.
主要方法:
- 一名66岁的妇女开始接受abemaciclib治疗乳腺癌,出现严重的功能障碍,腹和恶心.
- 诊断评估包括评估管损伤标志物和双侧扩大.
- 进行了脏活检,揭示了AIN的特征发现.
主要成果:
- 患者在开始服用abemaciclib.lib后不久表现出严重的功能障碍 (肌素15.16 mg/dL).
- 脏活检证实了AIN与 mononuclear细胞和eosinophils,管状炎和上皮细胞损伤的间歇性透.
- 在葡萄糖皮质激素治疗和补液后,功能显著改善,肌素水平在两个月内降至大约2mg/dL.
结论:
- 阿贝马西克利布可以引起急性间歇性炎 (AIN),导致严重的功能障碍和壮症,即使短期使用.
- 这一案例强调了考虑abemaciclib作为AKI患者出现AIN的潜在原因的重要性.
- 脏活检对于准确的诊断和指导适当的治疗至关重要,如葡萄糖皮质类药物治疗,用于药物诱导的AIN.
更多相关视频
05:18Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
Published on: May 26, 2023
1.8K
07:15Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
872
相关概念视频
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
01:27Acute Pyelonephritis I: Introduction
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...