甲状腺功能过高和肝衰竭患者的治疗:一项回顾性队列研究
Zhanyi Li1, Xiangyong Li1, Xiaoqiong Shao1
1Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Tianhe District, Guangzhou, Guangdong, 510630, China.
BMC gastroenterology
|September 30, 2025
概括
治疗肝功能衰竭的甲状腺功能障碍,包括单独使用甲基马 (MMI) 或使用人工肝支持系统 (ALSS) 和放射性 (131I) 加上ALSS,表现出类似的疗效. 增加ALSS缩短了住院时间.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 甲状腺功能障碍与肝衰竭相结合,具有显著的死亡风险.
- 这种复杂疾病的最佳治疗策略仍然不确定.
- 这项研究调查了临床特征和治疗结果.
研究的目的:
- 为了比较不同治疗方案对由肝衰竭复杂的甲状腺功能增强症的有效性.
- 评估人工肝支持系统 (ALSS) 对患者治疗结果的影响.
- 根据患者的特征,确定最合适的治疗选择.
主要方法:
- 一项对137名被诊断患有甲状腺功能升和肝功能衰竭的患者进行的回顾性队列研究 (2013-2022年).
- 患者接受了甲基马 (MMI) 加上ALSS,I加上ALSS,或单独使用MMI,持续24周.
- 倾向性得分匹配用于比较治疗组,监测肝脏和甲状腺功能.
主要成果:
- 在任何时间点,在MMI加ALSS和MMI单独之间没有发现治疗疗效的显著差异.
- 与单独使用MMI相比,I加ALSS也没有显著的疗效差异.
- 接受ALSS (MMI或131I) 的患者住院时间较短,各组不良事件没有显著差异.
结论:
- 甲基马 (MMI),131I加ALSS,以及MMI加ALSS都是治疗肝功能衰竭的甲状腺功能增强症的有效治疗方法.
- 整合ALSS可以加快患者的康复时间.
- 临床医生可以根据个体患者的个人资料在这些有效的治疗方法中进行选择.
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