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脑性淋巴瘤症呈现快速进展的帕金森症和霍尔姆斯震:一个病例报告

Tsukika Iguchi¹, Tsuyoshi Furuya², Takahiro Koinuma¹

¹Department of Neurology, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima, Tokyo, Japan.

|September 30, 2025

概括

脑淋巴瘤 (LC) 是一种罕见的脑淋巴瘤,可以模仿帕金森病,症状包括认知能力下降和震. 早期诊断至关重要,即使是异常呈现.

科学领域:

神经学神经学
在瘤学瘤学.
放射学放射学是指放射学

背景情况:

脑性淋巴瘤 (LC) 是一种罕见的中枢神经系统原发性淋巴瘤 (PCNSL) 亚型.
具有无质量形成的扩散透的特征,LC通常会导致认知能力下降和步态问题.
像帕金森症和福尔摩斯震这样的非皮拉米德形状症状是极其罕见的LC表现.

研究的目的:

报告一个独特的Lymphomatosis cerebri病例,呈现出非典型的神经症状.
为了突出与这种罕见疾病相关的诊断挑战.
强调在运动障碍的差异诊断中考虑LC的重要性.

主要方法:

一位75岁的老人患有快速渐进的认知衰退,帕金森症和霍尔姆斯震的病例介绍.
大脑MRI揭示了扩散的非增强白质病变.
通过活检证实了诊断,显示了与LC一致的扩散大B细胞淋巴瘤.

主要成果:

患者表现出非典型的帕金森综合征,包括帕金森症和霍尔姆斯震.
神经成像显示了分散的白质异常,没有对比度增强.
活检证实了Lymphomatosis cerebri,尽管正常的多巴胺转运器成像.

结论:

大脑淋巴瘤症可以呈现出不寻常的帕金森综合征.
临床医生应考虑LC在快速进展的运动障碍与分散的非增强白质病变.
像ASL-MRI这样的先进成像可能有助于早期诊断和有针对性的活检.

关键词:

这是ASL-MRI.认知障碍认知障碍是一种认知障碍.扩散大的B细胞淋巴瘤.福尔摩斯震惊地了一下.脑部淋巴瘤发生病.运动障碍运动障碍神经瘤学神经瘤学帕金森症帕金森症主要中枢神经系统淋巴瘤

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