血管内大B细胞淋巴瘤呈现为通过脏活检诊断的脑髓炎:一个病例报告
Jun Ma1, Dejin Song2, Xiaolin Yu1
1Department of Geriatrics, Qilu Hospital of Shandong University, 107# Wenhua Xi Road, Jinan, 250012, China.
BMC neurology
|September 30, 2025
概括
血管内大型B细胞淋巴瘤 (IVLBCL) 可以模仿脑髓炎. 脏活检成功诊断出IVLBCL在一个多焦点大脑和脊髓病变的患者,导致化学疗法后的神经系统完全恢复.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 诊断多焦点大脑和脊髓病变是具有挑战性的,往往需要广泛的神经检查.
- 血管内大B细胞淋巴瘤 (IVLBCL) 是一种罕见的疾病,可以出现神经症状.
- 这一案例凸显了IVLBCL的诊断复杂性和独特的诊断方法.
研究的目的:
- 报告一个IVLBCL病例呈现为脑髓炎.
- 强调在神经系统疾病的差异诊断中考虑IVLBCL的重要性.
- 为了说明皮肤活检在诊断IVLBCL时的有用性.
主要方法:
- 一名43岁的男性呈现出进展性神经系统缺陷.
- 最初的调查包括脑和脊髓的MRI和腰部穿刺,表明炎症性脑筋炎症.
- 18F-FDG PET-CT显示脏吸收异常,导致通过皮肤进行脏活检以确定确诊.
主要成果:
- 患者最初出现了暗示脑栓塞的症状,后来出现了炎症性脑髓炎.
- 尽管对疑似炎症状况进行了治疗,但症状持续并恶化.
- 透皮脏活检证实了血管内大B细胞淋巴瘤 (IVLBCL),涉及脏,大脑和脊髓.
结论:
- 在患有多焦点中枢神经系统病变的患者的差异诊断中应考虑IVLBCL.
- 早期和准确的IVLBCL诊断对于有效的治疗和改善患者结果至关重要.
- 透皮脏活检可以成为IVLBCL的有价值的诊断工具,特别是当其他方法不确或禁用时.
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