一个两阶段的通过皮肤递送药物系统,包括非侵入性深层皮肤递送的Sono-Phase-change转移组
Yi Zhang1,2, Xiong He1,2, Xiang Mao1,2
1College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China.
Journal of nanobiotechnology
|September 30, 2025
概括
这项研究介绍了非侵入性深部透皮药物输送的声相变换转移体 (SPCT). 将SPCT与超声波相结合,可以提高药物透率和胆固醇治疗效率.
科学领域:
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
- 皮肤病学 皮肤病学
背景情况:
- 通过皮肤递送药物面临着由于角层屏障的挑战,这限制了皮肤深层疾病 (如化) 的疗效.
- 现有的方法往往缺乏精确的控制或是侵入性的,妨碍安全和有效的深层皮肤药物管理.
- 开发针对深层皮肤的非侵入性策略仍然是治疗应用中的一个重大障碍.
研究的目的:
- 开发一种新的两阶段透皮药物输送系统,用于非侵入性深层皮肤输送.
- 研究声相变换转移体 (SPCTs) 与低频低强度超声波 (LFLIU) 结合用于增强药物递送的疗效.
- 在 keloid 治疗模型中评估该系统的治疗潜力.
主要方法:
- 已经制定了封装 perfluoro-n-pentane 的 Sono-phase-change 转移体 (SPCT).
- 设计了一个两阶段的输送系统,集成了被动的表皮透和超声波诱导的活性微泡透.
- 进行了体外和体外研究,包括体裸体小鼠模型,以评估输送效率,深度和治疗结果.
主要成果:
- SPCT显示了稳定的封装和被动的表皮透.
- 超声波辐射诱导SPCT相变为微泡,使药物能够更深入,更活跃地透.
- 观察到皮肤药物递送效率,深度,数量和分布的显著改善.
- 与超声波组相结合的SPCT显示了最快的 keloid 体积减少和优越的治疗效果.
结论:
- 拟议的两阶段透皮药物输送系统提供了一种非侵入性和安全的方法,用于深层皮肤输送.
- 这种方法显著提高了药物输送深度和剂量,为治疗诸如化体等疾病提供了一个有希望的策略.
- 超声波与超声波相结合的声波相变转移体代表了跨皮疗法技术的新进展.
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