对于COPD的精确医学:表型,内型,生物标志物和可治疗的特征
Cong Xie1,2,3, Kepeng Wang4, Kai Yang1,2
1Institutes of Integrative Medicine, Fudan University, Shanghai, 200032, China.
Respiratory research
|September 30, 2025
概括
精准医学通过整合表型,内型和生物标志物来彻底改变慢性阻塞性肺病 (COPD) 护理. 这种方法可以为COPD患者提供个性化治疗,超越一般管理,以定制的治疗策略.
科学领域:
- 肺部医学 肺部医学
- 遗传学和基因组学 遗传学和基因组学
- 翻译医学是一种翻译医学.
背景情况:
- 慢性阻塞性肺病 (COPD) 是一种复杂,异质的呼吸系统疾病,临床表现和治疗反应各异.
- 目前的管理往往依赖于通用的方法,未能充分解决个体患者的变化.
研究的目的:
- 审查COPD应用精准医学方面的进展和挑战.
- 探索表型,内型,生物标志物和可治疗特征的整合,以优化患者护理.
主要方法:
- 关于COPD表型,内型和生物标志物研究的当前文献的综述.
- 对个性化COPD管理的"可治疗特征"框架的分析.
- 讨论未来的方向,包括多omics数据和机器学习.
主要成果:
- 现型和内型分类识别出不同的COPD亚组,这些亚组有可能产生不同的治疗反应.
- 生物标志物,如血中乙氨基酸细胞数量和唾液转录组学,有助于患者分层和向治疗选择.
- "可治疗特征"方法解决了除空气流限制之外的可修改因素,包括并发症和恶化触发因素.
结论:
- 精准医学为COPD管理提供了一个范式的转变,朝着主动的,个性化的治疗策略迈进.
- 对于生物标志物验证,标准化定义和临床翻译,需要进一步的研究,以充分实现精确的COPD护理.
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