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Updated: Jan 16, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

乳腺瘤上皮层-介质细胞过渡和细胞因子:一个系统的审查

Yian Chen¹, Haining Ding¹, Jiaqing Song¹

¹The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Chinese Medicine), No.54 Youdian Road, Shangcheng District, Hangzhou, 310006, China.

Cancer cell international

|September 30, 2025

概括

炎症性细胞因子在乳腺癌细胞中促进表皮-介质细胞过渡 (EMT),推动瘤的进展和转移. 针对这些细胞因子提供了潜在的治疗策略,以对抗乳腺癌的耐药性和复发.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

炎症与癌症的发展有关.
癌细胞可以经历表皮-介质细胞过渡 (EMT).
瘤微环境中的细胞因子和化学因子在恶性细胞中驱动EMT.

研究的目的:

评估细胞因子在乳腺癌中EMT中的作用.
研究向细胞因子在乳腺癌中的治疗潜力.

主要方法:

对Cochrane,Embase,PubMed和Web of Science数据库进行系统的文献审查.
搜索术语包括"细胞因子"",化学因子"",EMT"",乳腺癌"和相关术语.
分析了54篇关于乳腺瘤中细胞因子诱导的EMT的文章.

主要成果:

特定的细胞因子 (TNF-α,TGF-β,IL-6) 在乳腺瘤中促进EMT.
EMT涉及表皮标记物 (E-cadherin,β-catenin) 的下调和中酶体标记物 (N-cadherin,vimentin,fibronectin) 的上调.
诱导EMT的转录因子 (TWIST/ZEB/SNAI1/SNAI2) 被上调.

结论:

细胞因子诱导的EMT是乳腺癌进展和转移的关键因素.
向细胞因子或EMT信号通路可能会降低治疗耐药性并防止复发.
针对细胞因子的治疗策略显示出对乳腺癌治疗的希望.

关键词:

乳腺癌是什么? 乳腺癌是什么细胞因子 (cytokines) 是一种细胞因子.皮质 - 介质细胞过渡.系统性审查系统性审查

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