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改变肠道微生物群对小鼠急性消耗性运动后肠道免疫功能的影响

Guang Yang¹, Lina Gao², Yuqian Liu¹

¹School of Sports Science, Lingnan Normal University, Zhanjiang, 524048, Guangdong, China.

BMC sports science, medicine & rehabilitation

|September 30, 2025

概括

便微生物群移植 (FMT) 可以减轻急性消耗性运动对小鼠肠道健康的负面影响. FMT改善了肠道屏障功能和免疫反应,减少了未有运动经验的小鼠的炎症.

科学领域:

运动生理学运动生理学
微生物组研究的研究.
免疫学免疫学免疫学

背景情况:

强烈的运动和长期的训练可以改变肠道微生物群的组成.
这些变化可能会影响结肠透性和免疫功能.
了解这些影响对于管理运动引起的生理变化至关重要.

研究的目的:

为了研究肠道微生物群对结肠透性和免疫功能在急性消耗性运动后的影响.
评估便微生物群移植 (FMT) 在减轻运动引起的肠道障碍方面的治疗潜力.

主要方法:

小鼠接受了14周的中等强度训练或急性消耗性运动.
组包括对照组,没有运动,运动,酸盐缓冲盐水 (PBS) 移植 (PT) 和便微生物群移植 (FMT).
肠道透性,炎症和免疫反应的结肠和血清标志物被使用西布洛特和ELISA分析.

主要成果:

急性消耗性炼增加了结肠的ゾ努林,降低了奥克卢丁和ZO-1的表达,表明透性增加.
与PBS移植 (PT) 相比,便微生物群移植 (FMT) 显著减轻了这些透性变化.
与PT相比,FMT还降低了炎症标志物 (MD-2,TLR-4,CD14,血清LPS,IL-6) 和增加了结肠sIgA水平.

结论:

便微生物种移植 (FMT) 有效地减轻了小鼠的急性消耗性运动引起的肠道透性增加.
FMT增强了肠道免疫功能,由增加的sIgA水平证明.
在没有之前炼经验的小鼠中,FMT减少了全身炎症,并改善了肠道屏障完整性.

关键词:

剧烈的消耗性运动.便微生物群移植便微生物群移植肠道上皮质的透性肠道健康肠道健康肠道微生物组是什么意思

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