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Updated: Jan 16, 2026

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在1型糖尿病患者中使用不同的商用混合闭环系统进行血糖控制和可变性:随机对照试验的系统性审查和元分析
Sergio Di Molfetta1, Ludovico Di Gioia2,3, Irene Caruso1
1Endocrinology Unit, University Hospital "Consorziale Policlinico" of Bari, Bari, Italy.
Diabetes, obesity & metabolism
|September 30, 2025
概括
商用混合闭环 (HCL) 系统在1型糖尿病管理中表现不同. 这项对随机对照试验 (RCT) 的分析突出了各种HCL系统的时间范围 (TIR) 和HbA1c的差异.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 医疗技术 医疗技术 医学技术
背景情况:
- 1型糖尿病 (T1D) 的管理需要持续的葡萄糖监测和胰岛素输送优化.
- 混合闭环 (HCL) 系统代表了T1D自动胰岛素输送的进步.
- 商业HCL系统的比较性能数据对于临床决策至关重要.
研究的目的:
- 进行随机对照试验 (RCT) 的系统审查和元分析,评估T1D患者的商业HCL系统.
- 根据关键的血糖控制指标,对不同HCL系统的性能进行最新分析.
- 为了比较各种HCL系统在实现目标范围内的时间 (TIR) 和降低HbA1c水平方面的有效性.
主要方法:
- 在2025年4月18日之前,对四个数据库进行系统的文献搜索,并对会议记录进行手动搜索.
- 包括RCT比较商业HCL系统与T1D患者的替代胰岛素治疗2周或更长时间.
- 排除了涉及孕妇的研究;主要结果是时间范围 (TIR).
主要成果:
- 分析了涉及七个商业HCL系统 (CamAPS Fx,Control IQ,DBLG1,iLet BP,MiniMed 670G,MiniMed 780G,Omnipod 5) 的37个RCT. 这些RCT包括:
- 在儿童群体 (<18岁) 中,平均TIR范围从59.3% (MiniMed 780G) 到68% (控制IQ),平均HbA1c为7.4%.
- 在成年人群 (≥18岁) 中,平均TIR范围从63.1% (Omnipod 5) 到74.4% (MiniMed 780G),平均HbA1c为7.1%.
结论:
- 商业HCL系统在改善T1D患者的CGM指标和HbA1c水平方面表现出不同的有效性.
- 在HCL系统之间存在性能差异,影响血糖控制结果.
- 进一步的研究可能会阐明导致这些绩效差异的因素.
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