益生菌补充剂增强功能恢复,并调节小鼠的血清代谢
Joseph L Roberts1,2,3, Parker Kooima1, Jarred Kaiser3,4
1College of Health Solutions, Arizona State University, Phoenix, Arizona, USA.
概括
像Bifidobacterium longum这样的益生菌补充剂可以减少疼痛,并改善骨折后的恢复. 这些肠道细菌干预措施显示出在骨折患者中非药物疼痛管理的潜力.
科学领域:
- 微生物学和免疫学
- 整形外科和创伤学
- 神经科学和疼痛研究研究
背景情况:
- 骨折导致显著的疼痛和发病率.
- 肠道微生物群影响疼痛和炎症.
- 微生物群在骨折疼痛中的作用尚未得到充分研究.
研究的目的:
- 研究Bifidobacterium longum和Lacticaseibacillus casei对骨折相关疼痛的影响.
- 评估益生菌对功能恢复和骨折后代谢变化的影响.
- 探索针对骨损伤疼痛的微生物向疗法.
主要方法:
- 雌性C57BL/6J小鼠经历了单边的股骨骨折.
- 小鼠接受了Bifidobacterium longum,Lacticaseibacillus casei或车载补充剂.
- 分析了疼痛行为,功能恢复,骨矿物质密度和系统代谢学.
主要成果:
- Bifidobacterium longum适度增加了腰椎骨的矿物质密度.
- 这两种益生菌都显著减少了疼痛行为,并改善了功能恢复.
- 比菲多细菌长 (Bifidobacterium longum) 显示出更快,更强的止痛作用.
- 代谢分析揭示了神经递质和炎症通路的菌株特异性变化.
结论:
- 益生菌补充剂,特别是Bifidobacterium longum,可以缓解疼痛行为,并增强骨折后的功能恢复.
- 针对微生物群的策略为创伤性骨损伤提供了有希望的非药物干预措施.
- 益生菌调节系统代谢,影响疼痛信号通路.
关键词:
骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折,骨折.代谢物的代谢物.代谢生物组的代谢生物组微生物组是一个微生物组.疼痛 疼痛 疼痛 疼痛更多相关视频
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