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葡萄糖依赖性胰岛素型多和葡萄糖在饮食或腹手术诱导的减肥后
Amanda Finn1, Yenni Cedillo1, Marthe Aukan2
1Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA.
与其他减肥干预措施相比,Roux-en-Y胃绕道 (RYGB) 手术导致食后葡萄糖依赖性胰岛素型多 (GIP) 降低,葡萄糖水平提高. 这些荷尔蒙变化可能会影响休息能量消耗和胰岛素敏感性,影响长期的体重管理.
科学领域:
- 代谢手术 代谢手术
- 内分泌学 在内分泌学.
- 肥胖问题研究研究
背景情况:
- 严重的肥胖症带来了重大的健康挑战.
- 了解体内荷尔蒙的变化,对于减肥维护至关重要.
- 临床试验.gov 标识符:NCT04051190.0.gov 临床试验.gov 标识符:NCT04051190.gov 临床试验.gov 临床试验.gov 临床试验.
研究的目的:
- 为了比较单独的非常低能耗饮食 (VLED) 或与袖子胃切除术 (SG) 或Roux-en-Y胃旁路术 (RYGB) 对依赖葡萄糖的胰岛素特异性多 (GIP) 和葡萄糖的影响.
- 研究这些激素在减肥维护中的作用.
主要方法:
- 10周的干预比较单独VLED (n=15) 与VLED+SG (n=15) 与VLED+RYGB (n=14) 在严重肥胖的参与者中.
- 测量了血GIP和葡萄糖 (禁食和食后),胰岛素敏感性,呼吸系数,以及干预前后的休息能量消耗 (REE).
- 评估了激素度的差异及其与代谢结果的关联.
主要成果:
- 与SG组相比,RYGB组显示出更高的禁食葡萄糖和更低的食后GIP.
- 增加的食后葡萄糖与减少的松达指数 (以RYGB) 和增加的REE (所有组) 相相关.
- 增加的禁食GIP与增加的HOMA-IR相关.
结论:
- 与单独使用VLED或VLED+SG相比,RYGB显著改变了GIP和葡萄糖度.
- 这些荷尔蒙变化可能会影响REE和胰岛素敏感性,可能会影响长期减肥维护.
- 需要进一步的研究,以充分阐明导致减肥后减肥成功的机制.
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