针对使用质子抑制剂的中风患者肺炎风险的影响:回顾性病例对照研究
Shaokang Wang1,2,3, Mi Ou1,2,3, Haipeng Ban1,2
1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Brain and behavior
|September 30, 2025
概括
针可以降低使用质子抑制剂 (PPI) 的中风患者的肺炎风险. 每次访问超过11次针疗程显示出最好的预防效果,显著降低了肺炎风险.
科学领域:
- 神经学 神经学
- 综合医学是一个整体的医学.
- 肺部病理学 肺部病理学
背景情况:
- 脑卒中是全球主要的死亡原因之一.
- 质子抑制剂 (PPI) 对于预防中风患者胃肠道出血至关重要.
- 使用PPI与肺炎风险增加有关,这种并发症尚未研究针的预防作用.
研究的目的:
- 研究针在使用PPI的中风患者中预防肺炎的潜力.
- 评估针疗程与肺炎风险之间的剂量反应关系.
主要方法:
- 一项病例控制研究利用了天津医疗保健大数据公司 (2016-2019) 的数据.
- 用PPI治疗的中风患者被分为病例 (肺炎) 和对照 (无肺炎) 组.
- 使用倾向分数匹配和后勤回归分析来评估针的影响.
主要成果:
- 肺炎影响了11.11%的中风患者.
- 第一次针治疗后的每次额外针治疗都与6%的肺炎风险降低有关 (OR:0.94,p < 0.001).
- 接受7-11次 (OR:0.36,p < 0.001) 或>11次 (OR:0.21,p < 0.001) 的肺炎风险明显降低,相比于<3次.
结论:
- 针在减少PPI中风患者的肺炎风险方面显示出有前途.
- 更高的针疗程频率,特别是每次超过11次,显示出最重要的预防效果.
- 需要进一步研究针作为PPI诱导的中风患者肺炎的预防策略.
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