接受和承诺治疗对肝移植患者免疫抑制药物的动机和坚持的影响:一项随机对照试验
Serdar Saritas1, Serafettin Okutan2, Hasan Saritas3
1Department of Medical Biology, Faculty of Medicine, Malatya Turgut Ozal University, Malatya, Turkey.
Brain and behavior
|September 30, 2025
概括
接受和承诺疗法 (ACT) 在肝移植接受者中显著改善了对免疫抑制药物的坚持. 这种干预增加了动机和正念,这对长期的移植存活至关重要.
科学领域:
- 移植医学 移植医学
- 行为心理学 行为心理学
- 免疫学 免疫学 免疫学
背景情况:
- 肝移植接受者需要终身免疫抑制以防止移植的拒绝.
- 动机下降可能导致免疫抑制药物治疗方案的不良遵守.
- 接受和承诺疗法 (ACT) 显示出增强患者动机和治疗遵从性的潜力.
研究的目的:
- 评估ACT对免疫抑制药物的坚持的影响.
- 评估ACT对肝移植接受者的动机水平的影响.
主要方法:
- 一项随机对照试验,涉及140名肝移植接受者 (70名实验,70名对照).
- 实验组接受了8个会议的ACT程序.
- 使用坚持,正念和动机等级收集的数据.
主要成果:
- ACT显著增加了对免疫抑制药物治疗方案的坚持 (p < 0.05).
- 与对照组相比,ACT组的正念和动机分数显著更高 (p < 0.05).
- 两组之间患者特征没有显著的基线差异.
结论:
- ACT是一种有效的干预措施,用于改善肝移植接受者的免疫抑制药物坚持.
- 提高动机和意识意识是ACT改善坚持的关键机制.
- 建议使用ACT来通过更好地遵守治疗来提高长期移植存活率.
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