在孟加拉国,在不同连接组织疾病中使用利图西马布的经验
A S Abdullah1, M M Hassan, M A K Azad
1Dr Abu Sadek Abdullah, Associate Professor, Department of Cardiology, Bangladesh Medical University (BMU), Dhaka, Bangladesh.
Mymensingh medical journal : MMJ
|September 30, 2025
概括
利图西马布在孟加拉国患者中表现出良好的耐受性和短期疗效,这些患者患有不耐药的自身免疫性疾病,如类风湿性关节炎和全身性红斑狼. 这项研究强调了其在管理具有挑战性的结缔组织疾病方面的潜力.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 临床药理学 临床药理学
背景情况:
- 自身免疫性疾病带来了重大治疗挑战,特别是在资源有限的环境中.
- 患有类风湿性关节炎 (RA),系统性红斑狼 (SLE) 和初级斯乔格伦综合征 (PSS) 的患者往往对传统疗法产生耐药性.
- 关于孟加拉国人群在这些疾病中使用Rituximab等新生物药的疗效和安全性的数据有限.
研究的目的:
- 评估孟加拉国诊断为患有各种自身免疫性疾病的患者中rituximab的耐受性和临床疗效.
- 评估Rituximab在那些对孟加拉国可用的标准一线治疗无反应的患者中的有效性.
- 在这个特定的人群中记录与rituximab治疗相关的不良事件.
主要方法:
- 一个观察性,开放标签的临床试验,从2008年9月到2010年9月在孟加拉国达卡BSMMU进行.
- 20名患有RA,SLE或PSS的患者,不适应先前的治疗,被纳入并接受Rituximab治疗.
- 对患者进行了长达24周 (6个月) 的随访,以评估反应和安全性.
主要成果:
- 所有11名RA患者都实现了ACR 20反应 (100%).
- 在SLE患者中,一人实现了完全缓解,两人实现了部分缓解.
- 两名PSS患者实现了部分缓解,一名患者改善了45.1%;五名患者出现了不良事件,其中一人死于肺炎.
结论:
- 利图西马布在孟加拉国人群中表现出良好的耐受性和短期临床疗效,用于治疗耐火性自身免疫性疾病.
- 这项研究支持Rituximab作为一种可行的治疗选择,用于在标准治疗失败时挑战结合组织疾病.
- 需要进一步的长期研究来证实该地区的持续有效性和安全性.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
492
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
492
Connective Tissue Cell Types
4.0K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
4.0K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
493
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
493


