认知功能障碍,TYG指数和老年人的抑郁症之间的关联:基于NHANES数据库,2011-2014年
Qinghua Guo1,2, Chao Chen1, Libo Guo1
1Outpatient Department, Peking University Sixth Hospital;Peking University Institute of Mental Health; NHC Key Laboratory of Mental Health (Peking University); National Clinical Research Centerfor Mental Disorders (Peking University Sixth Hospital), Beijing, China.
Brain and behavior
|September 30, 2025
概括
认知障碍或高甘油三糖指数 (TyG) 的老年人面临抑郁症风险增加. 这些发现突出了预防老年人抑郁症的潜在目标.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 老年人认知功能,代谢健康和心理健康之间的相互作用尚未完全理解.
- 甘油三糖 (TyG) 指数正在成为胰岛素抵抗和代谢功能障碍的标志物.
- 抑郁症是老年人群的重大公共卫生问题,影响生活质量.
研究的目的:
- 调查认知障碍,TyG指数和老年人抑郁风险之间的关联.
- 为开发针对老年人抑郁症的预防策略提供证据.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2011-2014) 的横截面分析.
- 通过患者健康问卷-9 (PHQ-9) 评估抑郁症.
- 认知障碍是由学习/记忆,执行功能和注意力/处理速度测试中的表现低而定义的. 计算并分为四分之一的TyG指数. 使用多变量逻辑回归.
主要成果:
- 包括2042名老年参与者 (≥60岁);15.3%的人患有抑郁症.
- 认知障碍与患抑郁症的风险增加了2.64倍.
- 与最低四分位数相比,最高的TyG指数四分位数显示抑郁症的几率增加了1.61倍.
结论:
- 较高的TyG指数和认知障碍与老年人抑郁症状的增加有显著联系.
- 学习/记忆,执行功能和注意力/处理速度的缺陷与更高的抑郁可能性相关.
- 研究结果支持TyG指数和认知状态作为老年人抑郁风险的潜在指标.
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