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Updated: Jan 16, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

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TMTCrunch:一种替代分离的蛋白质原子图谱,用于预测分离引起的衰老和阿尔茨海默病的影响

Max Brazhnikov1, Tomiris Kusainova1, Anna S Kopeykina1

  • 1V.L.Talrose Institute for Energy Problems of Chemical Physics, Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow 119334, Russia.

Journal of proteome research
|September 30, 2025
PubMed
概括

我们开发了一个新的生物信息学工具TMTCrunch,用于分析阿尔茨海默病 (AD) 中的替代拼接蛋白质形式. 这种工具确定了870种新的蛋白质形式,揭示了它们与神经退行和潜在的治疗点的联系.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的疾病替代性拼接是一种替代性的拼接.后翻译修改后的修改蛋白质的功能 蛋白质的功能蛋白质与蛋白质的相互作用蛋白质组学 蛋白质组学

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A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
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