林纳克洛提德囊与复合聚乙烯甘醇结合在结肠镜肠道制备中的应用效果
Li-Wei Xue1, Yi-Qian Zhang1, Wei-Lai Yu1
1Department of Gastroenterology, Rui'an People's Hospital/The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China.
World journal of gastrointestinal surgery
|September 30, 2025
概括
与减少剂量的聚乙烯糖醇电解液 (SF-PEG) 结合的林卡洛提德囊显示了改善肠道制备质量的趋势. 这种组合可能为结肠镜准备提供更好的替代方案,可能减少SF-PEG剂量和不良事件.
科学领域:
- 胃肠病学和内镜检查
- 药理学和药物开发领域
背景情况:
- 复合聚乙烯糖醇电解液 (SF-PEG) 是用于结肠镜检查的标准肠道清洁剂.
- 单剂SF-PEG配方可能并不总是达到最佳的肠道制剂.
- 利纳克洛提德增强小肠液分泌,促进周平静,这表明与SF-PEG的潜在协同作用.
研究的目的:
- 为了评估结合林纳克洛提德囊与SF-PEG用于肠道制剂的疗效和患者耐受性.
- 为了比较不同的肠道准备方案,包括林纳克洛提德和不同的SF-PEG剂量.
主要方法:
- 对2023年1月至12月接受结肠镜检查的116名患者的回顾性分析.
- 三组进行了比较:A组 (3L SF-PEG + 利纳克洛),B组 (3L SF-PEG) 和C组 (2L SF-PEG + 利纳克洛).
- 使用波士顿肠道准备量表 (BBPS) 评估肠道准备质量,以及完成率,病变检测和不良事件.
主要成果:
- 在BBPS得分,完成率,腺瘤/息肉检测,插入时间或患者满意度方面没有观察到跨组的显著差异.
- 在停药时间 (P=0.027) 和不良反应率 (P=0.029) 中发现了统计学上显著的差异.
- 与B组 (3L SF-PEG) 相比,C组 (2L SF-PEG + linaclotide) 的戒断时间和不良反应率显著降低.
结论:
- 利纳克洛提德囊显示了改善肠道准备质量的趋势.
- 将利纳克洛提德与减少剂量的SF-PEG (2L) 结合使用可能会减少不良反应和停药时间.
- 这种组合疗法需要进一步研究,以优化临床肠道制备方案.
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