在本地晚期直肠癌中观察和等待:进化,当前证据和未来的方向
Andrés García-Fernández1, Pilar Del Pozo-Elso2, Arantxa Villadóniga-Sánchez2
1Department of General Surgery, Virgen de la Luz Hospital, Cuenca 16002, Castille-La Mancha, Spain. angarciafernandez@sescam.jccm.es.
World journal of gastrointestinal surgery
|September 30, 2025
概括
局部晚期直肠癌 (LARC) 的管理正在通过观察和等待和全新辅助疗法等策略取得进展. 这些方法旨在改善治疗结果和生活质量,同时尽量减少治疗副作用.
科学领域:
- 在瘤学瘤学.
- 外科胃肠道外科手术
- 辐射瘤学 辐射瘤学
背景情况:
- 局部晚期直肠癌 (LARC) 的治疗方法已经在几十年内发展.
- 瘤生物学和技术的进步推动了LARC管理的变化.
- 多学科方法对于有效的LARC护理越来越重要.
研究的目的:
- 审查LARC管理的历史进展.
- 突出最近的突破重塑LARC治疗范式的突破.
- 讨论新型治疗方法的整合,以改善患者的治疗结果.
主要方法:
- 对LARC治疗的历史数据和当前文献的审查.
- 强调新辅助疗法策略,包括观察和等待和全新辅助疗法.
- 包括微创手术技术和新兴的向疗法/免疫疗法.
主要成果:
- 观看和等待策略在特定患者中提供了降低发病率和维持功能的潜力.
- 总的新辅助疗法正在成为一种标准的方法.
- 最少侵入性手术和向疗法/免疫疗法显示为个性化LARC治疗的前景.
结论:
- 创新旨在提高瘤学结果和患者的生活质量.
- 严格的患者选择和长期监测对于观察和等待至关重要.
- 为了优化LARC治疗策略并确保长期的安全性和有效性,必须采取多学科的方法.
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