基于预后免疫营养指数的营养分层增强了胃癌的恢复和生存:一个随机对照试验
1Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.
World journal of clinical oncology
|September 30, 2025
概括
使用预后免疫营养指数 (PINI) 的风险分层营养支持显著改善了胃癌患者手术后的康复和生存率. 这种方法提高了术后的结果和生活质量.
科学领域:
- 在瘤学瘤学.
- 手术营养是指手术营养.
- 免疫营养 免疫营养 免疫营养
背景情况:
- 手术后的营养不良,炎症和免疫功能障碍是胃癌恢复的关键挑战.
- 预后免疫营养指数 (PINI) 有助于风险分层,但其在术后营养中的作用未得到充分研究.
研究的目的:
- 评估基于PINI的风险分层营养支持是否能改善经过胃切除术的胃癌患者的康复,生活质量和长期结果.
主要方法:
- 一项前性随机对照试验,涉及195名胃癌患者,按PINI分数分层 (低,中等,高风险).
- 患者根据他们的风险组接受了量身定制的营养支持 (标准,密集或免疫增强).
- 包括BMI,白蛋白,PINI,睡眠质量,焦虑,抑郁,疼痛,生活质量,并发症,住院时间和生存时间在内的结局被术后评估.
主要成果:
- 接受免疫增强营养的高风险组在1年内显著改善了血清白蛋白,稳定了BMI,睡眠质量,并减少了焦虑和抑郁.
- 这组患者的疼痛评分最低,生活质量最高,并发症率最低 (3.3%),住院时间最短 (9.8天),存活1年时间最高 (98.5%).
结论:
- 基于PINI的分级营养支持有效地提高了术后恢复,并减少了胃癌患者的并发症.
- 这一策略改善了长期的结果,并支持其在胃癌的精确外科护理中使用.
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