在状细胞疾病中改变脑血流和功能连接
Daniel M Sop1, Yue May Zhang2, Wally R Smith2
1Division of General Internal Medicine, Department of Internal Medicine & Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23219-0306, United States.
Journal of sickle cell disease
|September 30, 2025
概括
患有状细胞疾病 (SCD) 的成年人表现出大脑血流增加和大脑活动改变,可能导致认知缺陷和更高的疼痛敏感性. 需要对SCD的脑向治疗进行进一步的研究.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 血液学 血液学 血液学
背景情况:
- 状细胞疾病 (SCD) 与认知缺陷和慢性疼痛有关.
- 这些症状背后的大脑机制尚不清楚.
- 在SCD中脑血流 (CBF) 升高可能会影响大脑功能和感知.
研究的目的:
- 为了研究SCD的成年人中大脑输液和休息状态大脑功能的改变.
- 探索这些大脑变化,认知和疼痛敏感性之间的关联.
主要方法:
- 动脉旋转标记 (ASL) 和静止状态功能性MRI (rs-fMRI) 在7名患有SCD的成人和3名健康对照中使用.
- 这些措施包括全球/区域CBF,静止状态功能连接 (rsFC) 和低频波动幅度 (ALFF).
- 用NIH工具箱测试评估认知功能,用疼痛敏感度问卷 (PSQ) 测量疼痛敏感度.
主要成果:
- 与对照组相比,SCD患者的全球CBF显著增加,皮质zALFF减少,白质zALFF增加.
- SCD参与者表现出静态网络超连接性,并且在默认模式和突出网络之间减少了反相关性.
- SCD患者表现出较低的处理速度和更高的疼痛敏感度;较高的CBF与较慢的认知相关.
结论:
- 患有SCD的成年人表现出大脑溢血,功能连接受损和大脑活动改变.
- 这些神经成像发现表明,在SCD中对认知减缓和疼痛敏感性增加的潜在贡献.
- 这些结果强调了研究SCD针对大脑的治疗策略的必要性.
相关概念视频
00:49The Blood-brain Barrier
Overview
01:23Transcellular Transport of Solutes
Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
01:14Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
01:19Cerebral Edema l: Introduction
Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...
01:22Cerebral Edema ll: Pathophysiology
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...