主要表现为男性末期脏病的系统性红斑狼:一个病例报告
1Department of Critical Care Medicine, Panyu Hexian Memorial Hospital of Guangzhou, Guangzhou, CHN.
Cureus
|September 30, 2025
概括
系统性红斑狼 (SLE) 可以在患有慢性病 (CKD) 的男性中微妙地呈现,延迟诊断. 早期的自身免疫查对于无法解释的多系统衰退至关重要,以防止致命的结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 类风湿病学 类风湿病学
- 内部医学 内部医学
- 病理学 病理学 病理学
背景情况:
- 系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病,具有多样化的临床表现.
- 慢性病 (CKD) 可能是SLE的早期或唯一表现,特别是在男性患者中.
- 在SLE的诊断延迟可能导致严重的并发症和增加的死亡率.
研究的目的:
- 报告一个单一的SLE病例,最初在男性患者中呈现为孤立的CKD.
- 突出SLE呈现中的诊断挑战和性别特异性考虑.
- 强调早期自身免疫查在患者中具有不明原因的多系统恶化的重要性.
主要方法:
- 病例报告详细介绍了一名37岁的男性,在血液透析中患有5年的CKD病史.
- 描述急性发展的泛cytopenia,低albuminemia,心脏生物标志物升高,和排泄.
- 通过自身免疫血清学确认SLE诊断,并讨论关键并发症.
主要成果:
- 这位患者出现了严重的胰腺减肥,低albuminemia,心脏生物标志物和多腔内泄露.
- 自身免疫血清学证实了具有特征性自身抗体的SLE.
- 并发症包括败血性休克,冠状动脉疾病,脏梗塞,脑出血和致命的多器官衰竭.
结论:
- 孤立的CKD可以掩盖男性患者的SLE发病,导致诊断延迟.
- 这一案例强调了需要对男性进行全面的自身免疫评估,这些男性患有不明原因的多系统衰退,即使没有经典狼症状.
- 早期的血清学查对于预防SLE诊断延迟和潜在的致命结果至关重要.
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