声学强度作为充血性心力衰竭恶化的潜在指标:一项探索性试点研究
Eran Hadad1, Jon Våbenø2, Herald Reiersen2
1Sanolla Ltd, Nesher, Israel.
Cardiology research and practice
|September 30, 2025
概括
呼吸道声音强度,包括超声波,显示出监测充血性心力衰竭 (CHF) 恶化的潜力. 这项试点研究在CHF患者中发现了声强度和氧和度 (SpO2) 之间的负相关性.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 肺部病理学 肺部病理学
背景情况:
- 充血性心力衰竭 (CHF) 需要持续监测患者,特别是在恶化期间.
- 脉冲氧计是重症监护监测的标准工具,在急性心力衰竭诊断方面显示出前景.
- 调查用于远程监测的新生理指标对于管理诸如心脏衰竭等慢性疾病至关重要.
研究的目的:
- 探索患有心血管衰竭的患者中氧和 (SpO2) 和呼吸声强度之间的关系.
- 评估呼吸声强度的潜力,包括超声波,用于远程医疗和自我监测应用.
- 为未来CHF恶化预测模型奠定基础.
主要方法:
- 收集了25名CHF患者的生理 (SpO2) 和声学数据,包括超声波.
- 在恶化阶段 (SpO2 <92%),分析了可听和可听+超声波范围内的SpO2与声强度之间的相关性.
- 使用了皮尔森相关性,并报告了调整后的p值和效应大小.
主要成果:
- 在几位CHF患者的恶化期间,在声强度和SpO2变化之间确定了显著的负相关性.
- 与仅仅听到的频率相比,纳入超声波频率提高了相关性大小和降低了p值.
- 经过调整后的分析证实,在两种频率范围内,在特定患者中仍然存在显著性.
结论:
- 试点研究显示,在CHF恶化期间,声强度和SpO2之间存在一致的中到强的负相关性.
- 声学强度显示出作为CHF恶化早期检测指标的潜力.
- 需要在更大的研究和预测建模框架中进一步验证.
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