人类免疫缺陷病毒感染患者的结构和功能异常:一个横截面的视角
Sivaprakash Sundaramoorthy1, Devarajan Radha2, Amalraj Ravi3
1Department of General Medicine, Government Tiruvannamalai Medical College and Hospital, Tiruvannamalai 606604, Tamilnadu, India.
World journal of nephrology
|September 30, 2025
概括
患有人类免疫缺陷病毒 (HIV) 感染的人群中,脏异常很常见,随着疾病的进展而恶化. 定期对脏进行监测对于早期检测和治疗这些脏缺陷至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 是一种进展性疾病,导致末期病.
- 人类免疫缺陷病毒 (HIV) 感染使CKD复杂化,增加并发症和恶化患者的结果.
- 艾滋病毒阳性个体的功能障碍给健康带来了重大挑战.
研究的目的:
- 为了评估被诊断为艾滋病毒感染的患者的结构和功能缺陷.
- 为了确定这一群体中脏异常的患病率和特征.
主要方法:
- 对227名艾滋病毒阳性成年患者进行了横截面研究.
- 排除标准包括先前存在的高血压,糖尿病,慢性病,肝病和毒药物使用.
- 数据收集包括病史,临床检查,血液测试和评估的超声波.
主要成果:
- 该研究群体的平均年龄为41岁,其中66.5%为女性;78%的患者使用基于Tenofovir的疗法.
- 超过一半 (54.6%) 的估计球膜过率 (eGFR) 低于60毫升/分钟/1.73米2.
- 脏异常很普遍:39.2%的脏膨胀,82.8%的声性增加;eGFR下降和脏大小增加与先进的HIV阶段相关.
结论:
- 结构和功能脏异常在艾滋病毒感染患者中很常见.
- 这些脏缺陷随着艾滋病毒疾病的进展而升级.
- 持续的脏监测对于管理艾滋病毒感染者的脏健康至关重要.
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