肺部和腹部的乳头核变化发生在精神病频谱的早期
Ciaran Browne1, Anurag Nasa1, Linda Kelly1
1Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences, Ireland.
Schizophrenia bulletin open
|September 30, 2025
概括
患有精神病经历 (PE) 的青少年表现出左侧脉动体体积的减少,这表明早期的神经改变. 这些发现表明,青少年精神病脆弱性的潜在早期标志物.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 精神病被视为一个频谱,轻度精神病体验 (PE) 在最低端.
- thalamus,特别是pulvinar,对于注意力和皮质同步至关重要,并且与精神病有关.
- 之前的研究指出,在严重精神病中,脉体积减少;本研究调查了青少年的亚临床PE.
研究的目的:
- 检查报告精神病经历 (PE) 的年轻青少年的乳头核体积变化.
- 在非临床的青少年样本中识别与下值精神病症状相关的早期神经解剖学差异.
主要方法:
- 一个社区样本95名青少年 (11-13岁) 有 (n=53) 和没有 (n=42) PEs接受了MRI.
- 在基线和2年和5年的随访期间,使用Freesurfer计算了thalamic核体积.
- 对共变率和线性混合效应模型的分析评估了群体差异和纵向变化.
主要成果:
- 患有PEs的青少年在2年和5年的随访期间左脉体积显著减少.
- 在长度上,在PEs组中观察到左脉体积的显著减少和左腹体积的显著增加.
- 这些发现被纠正为错误发现率 (FDR).
结论:
- 与精神病风险相关的乳头膜变化在患有下值PEs的青少年中可检测到.
- 这些神经发育偏差可能表明注意力和皮质同步电路的早期变化.
- 需要在更大的队列中进行进一步的研究,以确认发现并评估精神病脆弱性的预测价值.
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