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Updated: Jan 16, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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细胞膜向的J聚合策略,用于协同免疫检查点退化和免疫性烧死,以增强瘤免疫疗法

Xiaona Xu1, Hao Zhang1, Yahui Cao1

  • 1State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Key Laboratory of Functional Polymer Materials of Ministry of Education, Nankai University, Tianjin, 300071, P.R. China.

Angewandte Chemie (International ed. in English)
|September 30, 2025
PubMed
概括

这项研究引入了一种新的J-聚合物系统,可以降解PD-L1并通过光动力学疗法激活免疫反应,从而提高癌症免疫疗法的有效性,即使在缺氧瘤中也是如此.

关键词:
免疫原性细胞死亡在J-聚合.在PD-L1降解下降.光动力免疫疗法光动力免疫疗法热灭菌的发生.

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