在没有痴呆症的老年1型糖尿病患者的认知功能及其相关因素的纵向变化
Kaoru Nagasawa1, Kimio Matsumura1, Takayasu Uchida1,2
1Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Journal of diabetes investigation
|September 30, 2025
概括
患有1型糖尿病的老年患者随着时间的推移而经历记忆力下降. 糖尿病持续时间较长与认知障碍有关,即使没有痴呆症.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
背景情况:
- 1型糖尿病 (T1DM) 是一种慢性疾病,影响包括大脑在内的各种器官.
- 没有痴呆症的T1DM老年人的认知功能需要进一步调查.
- 纵向研究对于了解这一群体认知变化的进展至关重要.
研究的目的:
- 评估T1DM没有痴呆症的老年患者认知功能的纵向变化.
- 在这个群体中确定与认知衰退相关的因素.
- 评估T1DM持续时间和发病年龄对认知轨迹的影响.
主要方法:
- 包括患有T1DM且没有痴呆症诊断的老年患者 (≥65岁).
- 使用迷你心理状态检查和蒙特利尔认知评估 (日本版) 的认知评估在基线和3年后续.
- 认知衰退的定义是蒙特利尔认知评估得分在3年内减少≥2点;基线糖尿病相关因素的比较.
主要成果:
- 在3年内,整体迷你心理状态检查和蒙特利尔认知评估得分没有显著变化.
- 3年后,两个认知测试的延迟回忆子分数显著下降 (p=0.007,p=0.04).
- 认知能力下降与早期发病年龄 (β=0.54,p=0.026) 和较长的T1DM持续时间 (β=-4.77,p=0.026) 相关.
结论:
- 没有痴呆症的T1DM老年患者随着时间的推移呈现逐渐下降的记忆力.
- 延长T1DM的持续时间是认知能力下降的重要风险因素,独立于痴呆症.
- 早期发现和管理T1DM并发症可能对保持认知健康至关重要.
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